Our laboratory studies skin commensal fungi and their role in homeostasis and disease. We are interested in the immunological mechanisms that maintain fungal commensalism on the skin, which can however also contribute to skin inflammatory and allergic conditions. We aim at understanding these processes at a cellular and molecular level.
allergy, fungal commensals, infection, inflammation, Malassezia
The skin is densely colonized with microbes comprising not only bacteria but also fungi, which in the healthy skin live in equilibrium with the host. Under conditions of impaired host defences and defective skin barrier functions however, commensal fungi become associated with inflammatory and/or allergic disorders.
The causal relationship between fungal commensals and pathological skin conditions remains unclear. This important question calls for better understanding of the underlying cellular and molecular mechanisms of fungi-host interactions. An important aim of our work is to dissect how anti-fungal αβ and γδ T cells characterized by host-protective IL-17 production in the healthy skin get dysregulated and convert into pathogenic TH17 and TH2 cells in atopic individuals. A second interest of our group is devoted to the identification and characterization of fungal metabolites that can modulate tissue integrity and inflammation by engaging the host aryl hydrocarbon receptor (AhR).
We use the mouse as a model organism to address these questions. Collaboration with clinical partners will help to determine the importance of our findings for the human situation and to transfer our research results into clinical practice.
SKINTEGRITY.CH Principal Investigators are in bold: