Our research focus is on fibroblasts and extracellular matrix remodeling/fibrosis and associated inflammatory pathways. It spans from a preclinical molecular biology program focusing on the identification and characterization of key molecules to a translational and clinical program with emphasis on precision medicine and phase 2/3 clinical trial design.
inflammation, fibroblasts, fibrosis, systemic sclerosis, non-coding RNAs
Extracellular remodelling is a fundamental biological process occurring in many biologic and pathologic conditions including wound healing and fibrotic diseases. In our laboratory and clinical research, we are focusing on the chronic inflammatory autoimmune disease systemic sclerosis as a paradigm fibrotic disease. The overall goal is to identify molecular and cellular targets for therapy and develop them into targeted clinical therapies that are tested in appropriate clinical trials. To achieve this, we have used large scale screening (omics) approaches, and we developed novel advanced functional assays and a variety of animal models. We are using our biobanks to identify potential biomarkers for early proof of concept studies and disease prediction. We are also collaborating with the large international EUSTAR registry to model clinical trials and improve clinical trial design. We are contributing to the development of more sensitive disease measures in cooperation with our engineering partners. We eventually had the opportunity to join industry partners in the conduction of phase 2 and 3 registration trials, which lead to the clinical approval of new therapies for fibrotic diseases.
SKINTEGRITY.CH Principal Investigators are in bold: